Neo-Pain Relief PEA


PEA Pain Relief Anti-Inflammatory Supplement

NEO-100% NATURAL PAIN RELIEF™ contains a patented, superior form of Palmitoylethanolamide (PEA) and bioactive Bromelain that have been studied for their inflammation reducing properties. These purest ingredients work together to help prevent abnormal inflammatory response; reducing pain, swelling and preventing chronic inflammation from the sources. Happy Biopharma Inc. is a Canadian company that was the first to license PEA in Canada. This natural product is proudly made in Canada.

Natural pain relief and anti-inflammatory for:

  • nerve pain
  • muscle pain
  • chiari-like malformation CM
  • syringomyelia SM
  • joint pain: arthritis/osteoarthritis pain & neuropathic pain
  • cystitis and chronic urinary tract disease 
  • allergies (reduces itching and skin lesions)
  • idiopathic pulmonary fibrosis
  • kidney disease
  • IBD
  • diabetes
  • injuries/wound healing
  • cancer/mast cell tumors


NEO-PAIN RELIEF™ is a novel formula carefully designed to bring a tangible benefit for those living with inflammation and pain conditions. It contains; Palmitoylethanolamide (PEA), and Bromelain. Both work synergistically to treat the inflammation from the source, not only symptoms! Palmitoylethanolamide (PEA) is an endogenous lipid mediator with anti-inflammatory and anti-hyperalgesic properties. Cells can synthesize this molecule on demand. As soon as cells are under stress due to lack of oxygen, in situations of chronic pain or chronic inflammation, the cells form PEA as a cellular protector from the fatty compounds in their membranes. PEA then helps counteracting the stress. And if PEA has done its job, it will be gobbled up by the cell membranes again. PEA, acts by down-modulating mast Cells (MCs) following activation of the cannabinoid CB2 receptor and peroxisome proliferator-activated receptor-α (PPAR-α), a nuclear factor. How it works? PEA was first identified almost five decades ago in lipid extracts of various natural products, and its anti-inflammatory and antinociceptive effects were established later. Evidence exists that PEA is synthesised during inflammation and tissue damage and a number of beneficial effects including the relief of inflammation and pruritus(itchy skin) have been shown to be useful in the control of neurogenic and neuropathic pain.  In spite of the multitude of therapies currently employed to control inflammation, pain, pruritus (itching) and tissue damage. The possibility of using a natural compound, such as PEA to manipulate originating organism sources protective mechanisms may be considered a beneficial novel therapeutic strategy in Human and veterinary medicine. Bromelain (2000 DGU/g) Bromelain is a protein-digesting enzyme extracted from the flesh and stem of the pineapple plant. Benefits of bromelain include reducing inflammation and swelling, promoting wound healing, easing digestion, reducing muscular or joint pain, benefiting heart health, and reducing allergies or asthma.  

Inflammation – A Self-defense Process

Inflammation is a necessary process for survival of any species during infection, injury, damage and repair but persistent inflammation is the cause of numerous diseases. In healthy tissue there is a balance between agents that promote inflammation and those that block it. When there is an infection or injury, the pro-inflammatory agents (like tumor necrosis factor, interleukins, NF- kappaB etc) rally to eliminate the infection or damage and return the tissue to health. When health is restored, these pro-inflammatory agents return to normal levels. In some cases however, the immune system switches from an acute mode to chronic; low grade- inflammation that can persist for months or years. Low grade chronic inflammation is a feature of many chronic diseases including, atherosclerosis (damage of blood vessels), arthritis, diabetes, kidney disease, high blood pressure, cancer and even obesity!

Tackling Persistent Inflammation

One way is through the use of natural anti-inflammatory agents. Unlike the pharmaceutical agents, the natural agents have multiple benefits including: non-specificity, multiple mechanisms of action, considerably lower toxicity, synergistic action and many of these herbs have been used for hundreds of years. However, many of these natural ingredients are inherently poorly absorbed and therapeutic concentrations are difficult to achieve in tissues. Happy Biopharma Inc. is pleased to provide a novel and a powerful formula for addressing chronic inflammation.

NEO-PAIN RELIEF™ is a multiple ingredient formula with powerful, and patented ingredients that have been clinically studied. Moreover, these natural ingredients are subjected to a unique and safe process (industry first) that forms ultra-micronized particles that are small enough to easily penetrate the intestinal lining and enter the blood thereby considerably enhancing the absorption and bioavailability of these ingredients. The proof of course is in the results.

Each Veggie-Capsule of NEO-100% natural PAIN RELIEF™ contains:

Palmitoyl Ethanolamide (PEA)

The discovery that palmitoylethanolamide, a member of the N-acylethanolamine family which is produced from the lipid bilayer on-demand, is capable of exerting antiallodynic and anti-hyperalgesic effects by down-modulating both microglial and mast cell activity has led to the application of this fatty acid amide in several clinical studies of neuropathic pain, with beneficial outcome and no indication of adverse effects at pharmacological doses.

Collectively, over 3000 research studies have confirmed that palmitoylethanolamide act as a disease-modifying agent for controlling inflammatory responses and related chronic and neuropathic pain.

Bromelain (2000 DGU/gr)

Bromelain is derived from the stem of the pineapple plant (Ananas comosus).

The pineapple protease, bromelain, selectively inhibits the biosynthesis of proinflammatory prostaglandins (The prostaglandins are a group of lipids made at sites of tissue damage or infection that are involved in dealing with injury and illness. They control processes such as inflammation, blood flow, the formation of blood clots.) 


NEO PAIN P.E.A. is plant based from Italy.


15-20mg per lb body weight

small dogs/cats up to 22 lbs: 1/4 capsule twice/day.

medium dogs 23-54 lbs: 1/2 capsule twice/day.

large dogs 55+ lbs: 1 capsule twice/day.

Dr. Judy Morgan's Video about PEA



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